Tadalafil pka value

Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
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Please note: When using Cialis with a statin, it is important to let your doctor know if you are taking any other drug, including supplements.

Drinking too much alcohol during Cialis

interactions

Be sure to talk to your doctor before you use Cialis with a statin, as it may interact with other medications you are taking. If you experience any significant side effects, such as dizziness, lightheadedness, fainting, or numbness or tingly rashes, seek medical attention immediately.

Cialis and alcohol together can cause a potentially dangerous drop in blood pressure (hypertension), leading to dizziness, fainting, or stroke.

If you take Cialis with a statin, it is important to let your doctor know if you are taking any drug, including supplements.

Whether you can take Tadalafil at the same time as your other medications will depend on which medications you are taking.

You are required to complete a short medical consultation questionnaire that asks for any medications that you are prescribed from your GP and will indicate the medications that can’t be taken alongside Tadalafil.

There are several medicines which should not be taken concurrently with Tadalafil. Medicines which can have potentially serious interactions with Tadalafil include :-

• Any alpha-blocker medicines e.g. doxazosin (Cardura), alfuzosin (Xatral), tamsulosin, terazosin, or Flomax, that you can buy in the pharmacy. (These medicines may be used to treat prostate problems or high blood pressure).

• Isosorbide mononitrate, isosorbide dinitrate, or use a GTN spray or tablets

for chest pain or use Rectogesic ointment?

• Nicorandil (Ikorel), used to treat angina

• Cimetidine, used to treat stomach or duodenal (peptic) ulcers

• Theophylline, used to treat asthma

• Antibiotics:- Clarithromycin, Erythromycin and Telithromycin

• Anti-fungals such as itraconazole and ketoconazole

• Seizure medication:- carbamazepine, oxcarbazepine, phenobarbital, phenytoin and primidone

• Heart or blood pressure medication:- disopyramide, amiodarone, quinidine and procainamide

• Anti-viral medication:- telaprevir, atazanavir, retonavir, indinavir, saquinavir and cobicistat

• Recreational drugs:- amyl nitrate (poppers)

If you are taking any prescribed medication from your GP then you can simply write those in the “Is there any other medical information that you think our doctor should know?” section on the medical questionnaire. Then, our doctor will know whether the Tadalafil is safe for you to take.

Read available consultation questionnaire information online for “Tadalafil may be safe for you to take”, or if you are taking any prescribed medication from your GP before taking TadalafilDisclaimer :This is a sign-up form guide. The information and content posted on this website are for information purposes only and not intended to treat doctors only. Please seek advice from any kind of medical specialist before starting any new medicine, or to use any other medicine, and if you are considering starting treatment for your new medicine or medicine. If you are facing any health concern or illness then seek medical advice directly from your GP or any other specialist medical authority.

Please note that whilst we strive for the highest quality medicine as part of our business, we do not assume that all possible responses will correspond to our absolute highest level. However, the answers to questions about your answers will have to be confirmed by the answers to be considered as valid. If the answer to any question is not confirmed, or if the answer to any question is not accepted by the establishment, then it is assumed that the answer is not valid. If the answer to a question is accepted by the establishment, then it is assumed that the answer is not valid. The answers to these questions may be revised to better describe the answers provided.

Tadalafil belongs to the group of medicines called phosphodiesterase type 5 (PDE 5) inhibitors, primarily used to treat erectile dysfunction (impotence) and benign prostatic hyperplasia (BPH). Erectile dysfunction is the inability to keep a hard and erect penis suitable for sexual activity. Benign prostatic hyperplasia, also called prostate enlargement, is the non-cancerous growth of the prostate gland.

Tadalafil contains ‘Tadalafil’, which works by relaxing the blood vessels in the penis; this allows the blood to flow into the penis when the person is sexually excited. Thereby, it helps to treat erectile dysfunction. Tadalafil relaxes the bladder and prostate muscles, thereby reducing enlarged prostate symptoms such as difficulty in urination and urgent need to urinate.

You are advised to take Tadalafil for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as headache, back pain, muscle pain, pain in the legs and arms, nasal congestion, indigestion, and facial flushing. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take Tadalafil if you are taking nitrates (used to treat angina), riociguat (used to treat pulmonary hypertension) or alpha-blockers; if you have heart problems or stroke, low blood pressure or uncontrolled high blood pressure. Tadalafil is not intended for use in women. Tadalafil may cause dizziness, so drive with caution. Avoid consuming alcohol as it might cause increased dizziness. Tadalafil should not be given to children as safety and effectiveness have not been established. Keep your doctor informed about your health condition and the medicines you are taking to avoid unpleasant side effects.

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Notify your health insurance provider about any health conditions or now-for-fun>More information

USES OF Tadalafil

Tadalafil is used to treat erectile dysfunction (impotence) and benign prostatic hyperplasia (BPH).

SIDE EFFECTS OF Tadalafil

  • Headache
  • Acid reflux
  • Flushing
  • Indigestion
  • Muscle pain
  • Hearing loss

Who is at risk of getting Tadalafil side effects?

Tadalafil may cause side effects that may go away during treatment or may lead to some side effects not requiring medical attention if the side effects stop. If you are taking any other medicines, talk to your doctor as the may need to change the most common side effects you have ever experienced before. See the side effects section of the for the full list of medicines used in medicine.

Signs of an allergic reaction include hives, dizziness, wheezing or difficulty in breathing, swelling of the face, lips or throat, and hives.

Sudden vision loss in rare cases causes a severe drop in blood pressure. This can happen if you are not sexuallyodies sensitive or if you take nitrates, such as isosorbide, isosorbide mononitrate or isosorbide dinitrate, as well as take riociguat (Propranolol) if you are also taking these drugs. If you are taking isosorbide dinitrate or use Tadalafil along with this medicine, have a severe heart problem, a severe liver problem or a history of fainting.

If you experience symptoms of a serious allergic reaction, stop taking tadalafil and get Siegburg's Law consultation as soon as possible. This is the strongest line of action for all people. If you do not notice any changes in your symptoms within a few days, speak to your doctor about a different treatment option, such as a different medicine, such as a different brand of Tadalafil, or you can take a different medicine, such as a different brand of Tadalafil.

Finally, if you have severe liver or kidney problems, stop taking tadalafil and get medical advice from a doctor. If you are taking any other medication, please tell your doctor.

Whether you can take Tadalafil at the same time as your other medications will depend on which medications you are taking.

You are required to complete a short medical consultation questionnaire that asks for any medications that you are prescribed from your GP and will indicate the medications that can’t be taken alongside Tadalafil.

There are several medicines which should not be taken concurrently with Tadalafil. Medicines which can have potentially serious interactions with Tadalafil include :-

• Any alpha-blocker medicines e.g. doxazosin (Cardura), alfuzosin (Xatral), tamsulosin, terazosin, or Flomax, that you can buy in the pharmacy. (These medicines may be used to treat prostate problems or high blood pressure).

• Isosorbide mononitrate, isosorbide dinitrate, or use a GTN spray or tablets

for chest pain or use Rectogesic ointment?

• Nicorandil (Ikorel), used to treat angina

• Cimetidine, used to treat stomach or duodenal (peptic) ulcers

• Theophylline, used to treat asthma

• Antibiotics:- Clarithromycin, Erythromycin and Telithromycin

• Anti-fungals such as itraconazole and ketoconazole

• Seizure medication:- carbamazepine, oxcarbazepine, phenobarbital, phenytoin and primidone

• Heart or blood pressure medication:- disopyramide, amiodarone, quinidine and procainamide

• Anti-viral medication:- telaprevir, atazanavir, retonavir, indinavir, saquinavir and cobicistat

• Recreational drugs:- amyl nitrate (poppers)

If you are taking any prescribed medication from your GP then you can simply write those in the “Is there any other medical information that you think our doctor should know?” section on the medical questionnaire. Then, our doctor will know whether the Tadalafil is safe for you to take.

How to take tablets of TadalafilTadalafil tabletsThis medicine is available only with your GP. It’s best to ask any medical professional you same-day whether Tadalafil is safe for you to take.

This medication may be taken with other medicines such as :-

If you are taking any prescribed medication from your GP then you can simply write those in the “Is there any other medical information that your doctor should know?” section on the medical questionnaire.

Is there a high chance Tadalafil may reduce your blood pressure

The chance of experiencing a side effect of Tadalafil increases when you are exposed to the same or a different drug. A side effect that can occur at any time while taking Tadalafil is a drop in blood pressure that can cause a variety of symptoms, including nausea, vomiting, dizziness, lightheadedness, trembling, nausea, vomiting,/ onset of each, abdominal pain, and/ more. This could result in dizziness or fainting, especially when you’re new. So, you can take Tadalafil with your next meal of the day. However, if the side effect is too similar to the above then your doctor may change your next dose from now not having a new one. So, you can be moved to take a Tadalafil with a missed dose.